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Clinical data suggests that GIP co-activation with GLP-1 may also reduce nausea rates compared to GLP-1 stimulation alone, which could explain why Retatrutide and Tirzepatide cause less nausea than Semaglutide despite being more potent compounds
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Insulin is stored in the body as a hexamer, whereas the active form is the monomer
However, the differences in anatomy, physiology, genetics, and the gut microbiome-host interaction, among other factors between human body and animals, make many data from animals fail to translate into humans
