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2023 Aug 8;15(8):e43112

In addition, the photoreceptor cells in diabetic mice also showed enhanced levels of iron, ROS, and MDA and reduced GSH concentration with downregulation of GPX4 and SLC7A11, and upregulation of ACSL4, FTH1 and NCOA4, which suggested that ferroptosis is also involved in the pathogenesis of photoreceptor degeneration in the development of the early stages of DR (Gao et al., 2023)

Various cytokines can also impact vascular function and structure, as well as renal sodium transport, ultimately resulting in increased systemic vascular resistance, elevated blood pressure, and sodium and volume retention [214, 215]

However, excessive or chronic alcohol intake can have detrimental effects on various aspects of health, including liver function and hormone balance