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In fact, a strong argument can be made that B12/MIC is a particularly versatile inhibitor of mTOR precisely because its various components each work to combat distinct catalysts of mTOR stimulation
Another study using NR supplementation showed that doses up to 1000 mg per day for 10 weeks were well tolerated in patients affected by mild cognitive impairments (MCI) 246

doi: 10.1038/s41586-019-1707-0 27 KraftVANBezjianCTPfeifferSRingelstetterLMllerCZandkarimiFet al

Bellei, B