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The reasons of the inconsistency of the data could be due to a multiplicity of factors: RCTs are frequently undersized and the period is too short to evaluate the effect on hard outcomes

Low-density lipoprotein cholesterol (LDL-C) is well-acknowledged as playing a crucial role in the pathogenesis of CAD, and lowering of plasma LDL-C results in significant reduction in the morbidity and mortality of CAD [72, 73]