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Niacinamide 5%: Helps improve the appearance of dark spots and uneven tone and supports the skin barrier

On the other hand, the inhibition of Nrf2 signaling might be employed to enhance the sensitization of chemoresistant tumors to cytotoxic agents, and in this context, it has recently been reported that brusatol, a compound found in a plant extract, acts as inhibitor of this pathway and may exhibit therapeutic utility [111]

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Biochem J 1999
