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Cellular damage in DILI can reflect toxic effects of the culprit medication or its metabolites, or immune-mediated effects (Figure 1)
Glutathione is central to Phase II liver detoxification conjugating toxins, heavy metals, and metabolic waste products so they can be safely eliminated from the body
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S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant
