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However, one placebo-controlled study of ketorolac in postoperative infants showed no adverse effects on renal or hepatic function

TREM2 also modulates APOE isoform-specific effects: TREM2 deficiency exacerbates microglial A clearance deficits in APOE 4 mice (274), supporting TREM2-targeted therapies for APOE 4-associated AD

Li L, Rose P, Moore PK
Researchers believe the benefit derives from a newly discovered role for SOD1 as a self-regulating redox sensor for NADPH oxidase-derived O2 production
