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doi: 10.1038/s41593-020-00758-5 19 DanielsBPHolmanDWCruz-OrengoLJujjavarapuHDurrantDMKleinRS
GLS inhibition decreases the production of GSH in AML cell lines, leading to increased mitochondrial ROS and apoptosis [8, 24]
Nature 547 (7662), 222226 (2017)
This makes Long R3IGF-I significantly more potent (2-3x) than IGF 1 LR3 in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins, and consequently more potential activity in the body
