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Description
It is supposed that some of numerous changes occurring in regulatory proteins observed under acute or chronic cocaine injections could be related to the S-glutathionylation catalyzed by GSTP1-1

Proteomics 6, 39803992 (2006)

Potential solution Peptides/peptidomimetics can often be solubilized in DMSO at a high concentration up to 2050 mM range

As you can see from the diagram, the bioactive folate donates a methyl group to the amino acid homocysteine, which is then able to convert into methionine, which further goes on to form SAMe
