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Together, these signaling systems provide a framework for investigating how angiogenic signaling, cytoskeletal organization, and fibroblast-mediated extracellular matrix processes interact in laboratory models of tendon, ligament, and musculoskeletal tissue biology

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This fundamental difference leads to several practical distinctions

Given the lifelong need for B12 therapy in deficiency-prone populations, the selection of the most patient-friendly and economically sustainable option is critical
