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In parallel, the review examines the current status of clinical translation, summarizing key challenges such as limited bioavailability, formulation barriers, and patientspecific variability, while highlighting emerging opportunities including nanodelivery platforms, combination therapeutic strategies, and precision medicineoriented applications

This modification dramatically improved metabolic stability while eliminating the steroidogenic effects associated with full ACTH molecules

Forkhead box protein P1 (FOXP1), is a transcription factor that acts as an activator of Wnt signalling by promoting -catenin acetylation and its expression is increased in stromal cells of DIE [61]

Combining antioxidant-targeting agents with cell wall synthesis inhibitors has shown synergistic efficacy in model organisms, supporting combination therapies