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This polymorphism is similar to the wild type NQO1*1, results in substitutional messenger RNA splice sites that can result in a deletion of exon 4 and produce a protein deficient in quinone binding site for which enzyme activity differs according to the substrate [ 61 , 62 , 63 ]

Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells

It has been observed for many years that there is a correlation between increased lactate production rates and cell proliferation, particularly in cancer cells