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Analyzing a series of studies using differing amounts of B12 via injection, the IOM determined that 1.5 g of absorbed B12 per day was enough to normalize red blood cell parameters (hematocrit, red blood cell volume, and anemia) in the average patient with pernicious anemia

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The study was approved by the Ethics Committee of Thomayer Hospital and the Institute of Clinical and Experimental Medicine, Prague, Czech Republic and carried out in accordance with the approved guidelines