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DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable elements) and pathological processes (cancer and repetitive sequences-associated diseases) are regulated

In humans, melatonin accelerates falling asleep, reduces the number of nighttime awakenings, prolongs the total duration of sleep, and improves its quality. SLEEP REGULATION PROCESSES Two processes participate in sleep regulation: homeostatic and circadian

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