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As the pathological burden increases, this metabolic dysregulation may eventually evolve into hepatic fibrosis, cirrhosis, or even further development of hepatocellular carcinoma [75]
Frataxin is an iron chaperone that drives the assembly of the Fe-S cluster in mitochondria, while it has recently been identified as a key regulator of ferroptosis by modulating mitochondrial iron homeostasis [140]
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Their role in neuroprotection is primarily attributed to their ability to mitigate oxidative stress, reduce neuroinflammation, modulate neurotransmitter activity, and enhance neurogenesis (Butterfield and Halliwell 2019)
