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Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Absent Core Comorbidities: Absent Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility with skin involvement Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Present Core Comorbidities: Absent Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility with core comorbidities Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Absent Core Comorbidities: Present Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility with core comorbidities and with skin involvement Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Present Core Comorbidities: Present Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, musculoskeletal subtype Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Absent Core Comorbidities: Absent Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, musculoskeletal subtype with skin involvement Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Present Core Comorbidities: Absent Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, systemic subtype Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Absent Core Comorbidities: Present Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, systemic subtype with skin involvement Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Present Core Comorbidities: Present Vascular EDS (vEDS) Genetic testing is used to see if a person has a genetic variant that causes vEDS

All samples were normalized to GAPDH mRNA levels

The Oil Red O staining LO2 and HepG2 cells were analyzed with Image-Pro Plus 7.0 image analysis software

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