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At the same time, metformin restored the membrane potential, reducing mitochondrial proton leak and ROS generation by inducing the expression of superoxide dismutase 2

63 In contrast, in human articular chondrocytes isolated from osteoarthritis patients, BMP2 increased OXPHOS instead of glycolysis whereas TGF1 exhibited the opposite effects

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In addition to the safety and efficacy of inhaled drugs in the lung, the lung biopharmaceutical properties should also be fully evaluated in drug design to ensure that inhaled nano-based drugs can maintain pharmacodynamic concentration in lung tissue for a long time