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Downregulation of HIF1 target genes during RG differentiation To obtain more insight into the molecular mechanism of the HIF1mediated prevention of precocious RG differentiation, we investigated whether the switch from RG expansion to neurogenic commitment was associated with a regulation of HIF1 target genes

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History [edit] In the posthumously published Ortus Medicinae (1648), Jan Baptist van Helmont made the first proposal of a RCT, to test two treatment regimes of fever