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In addition to these classical mechanisms, emerging processes such as ferroptosis (iron-dependent cell death), impaired autophagy, gut microbiota dysbiosis, and epigenetic alterations offer promising therapeutic targets
Metabolic pathways are prominent findings of global, agnostic analyses of the kidneys from animal models of hypertension, similar to findings from human kidney biopsies with hypertensive nephrosclerosis 43
Highly variable amounts of selenium were reported in wells from seleniferous areas in the USA ranging from non-detectable levels to 330 g/litre (Smith & Westfall, 1937)
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