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In educational frameworks, DSIP is positioned at most for the patient with documented, persistent sleep-architecture problems who has genuinely failed sleep hygiene, CBT-I, and melatonin, and who explicitly understands they would be engaging with something investigational rather than a validated treatment

Insulin activates mTOR (mechanistic target of rapamycin), which phosphorylates and inactivates ULK1 the initiating kinase required for autophagy pathway formation

Some classical antidepressants target on serotonin, norepinephrine, and dopamine are the predominant drugs used in current clinical practice [10]

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