dihexa pka values — Hans Reich Collection — Table 1 from Rapid Determination

This fast clearance reflects the dominant degradation mechanism: N-terminal cleavage of tryptophan by plasma and CSF aminopeptidases

Vermersch for their contribution to the peer review of this work

Mechanistically, the phagocytosis of apoptotic podocyte debris by macrophages triggers the activation of the NLRP3 inflammasome, which in turn promotes the maturation of IL-1 and IL-18, thereby establishing a podocyte-macrophage interactive damage cycle (35)

As machine perfusion continues to advance, ESOT 2025 underscored its growing role in expanding the donor pool, enhancing transplant logistics, and supporting the future of precision transplant medicine