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2) CGI-S and Improvement (CGI-I) Scales

Kigerl KA, Ankeny DP, Garg SK, Wei P, Guan Z, Lai W et al (2012)

[64] propose that commensals in the gut activate TLR-MyD88 signaling

Berberine activates AMPK through a different mechanism than MOTS-c (via inhibition of complex I in mitochondria), so concurrent use may create additive rather than synergistic AMPK activationhigher risk of hypoglycemia without proportional metabolic benefit
