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When cells are exposed to OS, gene mutations and other factors, the degradation of Nrf2 by the above complex may be impaired, such as: pro-oxidant conditions, autophagy disorders inhibit the combination of Keap1 and Nrf2 (Jain et al
& Hernndez-Hernndez, Inhibition of xanthine oxidoreductase enhances the potential of tyrosine kinase inhibitors against chronic myeloid leukemia

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