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doi: 10.1016/j.jpha.2020.05.007 81 TodaMMizuguchiSMinamiyamaYYamamoto-OkaHAotaTKuboSet al

23 The oxidation pathway begins with aminotransferase-mediated deamination and transfers the amino group to alpha-ketoglutaric acid to form glutamate to enter the urea cycle

The universal role of NADPH as the primary electron donor for most biological reductions, including for supporting disulfide reduction systems, made the uncovering of an apparently NADPH-independent disulfide reduction system in mouse liver surprising

Impaired Detoxification : Lower glutathione levels can hinder the bodys detoxification processes, making it more challenging to eliminate toxins and waste products