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Subacute exposure to lead results in GSH pool depletion and accumulation of lipid peroxidation products and modifies the activity of the glutathione-related enzymes, such as GR, GST and glucose-6-phosphate dehydrogenase [16]
294,295 However, some clinical trials have shown no benefit, 296,297 so the value of arginine supplementation needs to be further tested

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