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Gore, E

In addition, Irg1-deficient phagocytes, which cannot produce itaconate, have shown increased susceptibility to M.tb infection, with infected mice exhibiting higher bacterial loads, reduced survival, exacerbated inflammation, extensive necrotizing granuloma formation and elevated neutrophil infiltration in the lungs [104, 105]

Cystic Fibrosis (CF) CF is a genetic disorder affecting multiple organ systems including the lungs and upper airways, pancreas, liver, intestine, and reproductive organs [51]

More recently, single-cell and spatial technologies have resolved the heterogeneity and physical niches of lipid metabolism