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Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (83)

Induction of Th1-dependent immunity by an orally effective melon Super Oxides Dismutase SOD, Current Trends in Immunology, Vol 5, 2003, I

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