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Description
initially reported that that CD38 is activated during I/R injury in isolated rat hearts
Vinuela, A

Possible Side Effects 5-Amino-1MQ is generally well tolerated in preclinical studies

Our present results indicate that treatment with a heavy-chain anti-CD38 antibody selectively targeting the ectoenzyme domain, but not with an anti-CD38 antibody that does not block ectoenzyme, prevented bleomycin-induced weight loss, skin fibrosis and architectural remodeling in the lung, accompanied by reduced collagen deposition and significant improvement of pulmonary functions
