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Just be aware that there is high altitude (in Puno and Cusco) and some walking involved

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J Neurol Disord 1:107 Duda CD (2012) Dietary and Biochemical Markers of Folate in the Consideration of Depression

Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer
