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History of Malignancy Per FY2026 ICD-10-CM Official Guidelines Section I.C.2.d: When a primary malignancy has been previously excised or eradicated from its site and there is no further treatment directed to that site and there is no evidence of any existing primary malignancy at that site, a code from category Z85, Personal history of malignant neoplasm, should be used to indicate the former site of the malignancy. A patient currently receiving adjuvant chemotherapy, radiation, or immunotherapy still has treatment directed to that site therefore, use the active C-code, NOT Z85