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Similar content being viewed by others Introduction Pancreatic cancer(PC) is one of the most lethal malignancies with a 5-year survival rate less than 9% [1]

However, high-dose purified EPA formulations (4,000 mg/day EPA alone) were associated with a 50% relative increase in bleeding events, though this translated to a modest absolute risk increase of only 0.6% (247)

The peptide mechanisms of action are not gender-specific, and the safety profile appears comparable across genders

In this review, we provide an mtROS-centered framework to bridge this gap by integrating anatomical and histopathological changes with mitochondrial dysfunction, redox dysregulation, and catabolic signaling in rotator cuff injury-induced supraspinatus atrophy