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In preclinical studies, metformin activates AMPK via inhibition of mitochondrial complex I, enhancing mitochondrial biogenesis and mitophagy [148], while pioglitazone promotes fatty acid oxidation, energy production, and reduces neuroinflammation [149]

Conclusions Gut microbiota generate a plethora of biologically active metabolites that can exert a powerful direct or indirect influence on many aspects of host homeostasis and pathophysiology
Carnitine in Renal and Dialysis-related Nutrition Management What is the role of carnitine in managing patients with renal or dialysis-related nutritional issues

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