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Following fasting and calorie restriction, hormone insulin-like peptide 5 (INSL5) secreted by colonic L-cells is increased 56


In contrast, foods rich in dietary fiber increase the diversity of the gut microbiota and the production of metabolites, including SCFAs, which have anti-inflammatory effects (160, 161)

Fission of mitochondria (2) is carried out by the Drp1 GTPase, which is recruited to the OMM from the cytosol
