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The activation of PLC results in the release of inositol-1,4,5-trisphosphate (IP 3 ) from membrane associated phosphatidylinositol-4,5-bisphosphate (PIP 2 ), which then binds to specific IP 3 receptors in the endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) resulting in the release of intracellular stores of Ca 2+

While a more direct comparison of interactions between these components is required, the above results seem to be at odds with the notion that GR activity is solely required for the classical ascorbate-glutathione pathway

[Source: Manufacturer Product Specifications] | The cream is formulated to combat melanin pigmentation and deliver a brighter, even-toned complexion