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J J Wurtman

Expression of DBC1 and androgen receptor predict poor prognosis in diffuse large B cell lymphoma

The Need for Confirmatory Diagnostics Accurate prognosis depends on a diagnosis Identification of a specific therapy depends on a diagnosis Premature institution of corticosteroid therapy without an adequate diagnostic work-up may lead to delays in or failure to establish an accurate diagnosis Delay or failure to obtain an accurate diagnosis can result in irreversible damage to skeletal muscle in treatable disorders such as masticatory muscle myositis or polymyositis Delay or failure to obtain an accurate diagnosis can result in death in cases of myasthenia gravis due to aspiration pneumonia or respiratory failure An accurate diagnosis is critical to the development of DNA based testing for genetic diseases of purebred dogs Remember the Myopathic Effects of Corticosteroids

In our results, the increased ezrin expression after PTZ administration indicates the activation of the astroglial cells suggesting that systemic PTZ treatment enhances astrocytosis in the brain