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On the contrary, SerpinB2 depletion in macrophages kindled pro-inflammatory cytokine production with concomitant high oxidative phosphorylation and apoptosis of VAT resident macrophages, indicating the role of SerpinB2 in controlling exaggerated mitochondrial respiration, inflammation, and VAT resident macrophage survival in obesity

doi: 10.1089/ars.2007.1628 33 SemenzaGL

Rubbing it can irritate the area and slow down the healing process
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