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That make the process harder to sustain

These processes contribute to the development, progression and metastasis of various solid tumors, including hepatocellular carcinoma, colorectal cancer, and pancreatic ductal adenocarcinoma [388]

Conversely, the increased activity of Nrf2 is effective for the prevention of chemical carcinogenesis

It is essential for brain function, ensures the maintenance of neuronal homeostasis, and it plays a leading role in cognitive processes such as learning and memory and in keeping neuronal circuits functionally intact 2