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Variability in NFE2L2 and KEAP1 mutations, coupled with nongenetic mechanisms such as p62/SQSTM1 accumulation, results in highly variable NRF2 activity across tumors, complicating the unification of therapeutic approaches [5, 56]
spironolactone, an antagonist for the aldosterone receptor

A.BjorklundG.et al

assessed antioxidant capacity through the Folin-Ciocalteau and Trolox equivalent antioxidant capacity assays, noting that pH had a more significant impact on antioxidant capacity than the addition of cysteine