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Using a near-infrared marker, researchers monitored the in vivo fate of the microspheres following administration into healthy rat joints or mildly collagenase-induced OA joints and revealed a retention time of up to 70 days
For keeping vitamin B12 levels up, a common dose is 1000 mcg (1 mg) once a month

Ahmadian M, Dabidi Roshan V, Ashourpore E

Dermatology 1997
