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However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels

Moreover, pharmacological induction of autophagy by rapamycin alleviates APAP hepatotoxicity through removal of damaged mitochondria and detrimental APAP-ADs [86], [87], indicating the induction of autophagy as a novel therapeutic approach for AILI

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However, long-term studies specifically tracking extended use are lacking