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A new animal model for Polygonum multiflorum Thunb-induced liver injury in rats and its potential mechanisms

However, this alone cannot explain a 10-fold increase in energy demand, and many other processes may also become very costly in energy

Such findings align with preclinical models showing that prolonged ethanol exposure induces persistent neuroadaptations in mood-regulating circuits, including the prefrontal cortex, hippocampus, and amygdala (Hasin and Grant 2015)
