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AMPK activation inhibits expression of proinflammatory mediators through downregulation of PI3K/p38 MAPK and NF-B signaling in murine macrophages

Compared with the wild type (WT) protein, K240A exhibits an increased k cat toward tyrosine and a decreased k cat toward DOPA

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It was a double-blind, randomized, placebo-controlled clinical trial approved by the FMB-Unesp Institutional Review Board