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Efflux transporters in brain capillary ECs further enhance the BBBs protective function by actively removing undesirable substances and metabolic byproducts from the brain into the systemic circulation

Diagnostic Assessment Inflammatory and Regulatory Markers C4a: 5600 (elevated) TGF-1: 7210 (markedly elevated) MMP-9: normal VEGF: normal MSH: normal ADH/osmolality: normal Mycotoxin Testing Elevated ochratoxin A Elevated gliotoxin Presence of aflatoxins, trichothecenes, zearalenone Lyme disease: negative Epstein Barr Virus: negative Clinical Interpretation Findings indicated: Significant toxin burden Partial inflammatory activation The absence of widespread biomarker abnormalities suggested a non-CIRS mycotoxin illness with immune involvement

[DOI] [PubMed] [Google Scholar] [66].Ristoff E, Larsson A

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