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For example, icariin (ICA) can upregulate GPX4 expression, reducing MDA levels and iron content in synovial cells, thereby activating the System Xc /GPX4 axis to inhibit ferroptosis and alleviate synovial inflammation ( Combining GPX4 with iron chelators, antioxidants, or free radical scavengers such as Fer-1, Lip-1, vitamin E, or edaravone can further enhance its protective effects, reducing lipid oxidative damage and slowing OA progression (Xu Y et al., 2023)

M., & Millard, M

First, samples were processed by adding lysis buffer (1.5% SDS/100 mM Tris-Cl), homogenized, and centrifuged to obtain supernatants

En incorporant du glutathion dans sa formulation, ce srum aide prvenir la dgradation du collagne et combattre les signes du vieillissement , prservant ainsi la fermet de la peau