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Lipid peroxidation products such as malondialdehyde, 4-hydroxynonenal and isoprostanes, impair membrane function, inactivate membrane-bound receptors, and increase tissue permeability

GABA (gamma-aminobutyric acid) interneurons are the main inhibitory neurons in the central nervous system (CNS), and they play a critical role in a variety of pathophysiological processes including modulation of cortical and hippocampal neural circuitry and activity, cognitive function-related neural oscillations ( eg , gamma oscillations) and information integration and processing