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Neither supplement is recommended in NICE guidance for diabetes management

Vitamin B12, also known as cobalamine, is an essential water-soluble vitamin

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This therapeutic inhibition is important to increase the availability of levodopa at the central level and to reduce undesirable peripheral effects, such as the activation of the chemoreceptor region of the area postrema, which is located outside the blood-brain barrier and whose activation by dopamine causes important emesis
