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Oxidative stress and cellular response to doxorubicin: a common factor in the complex milieu of anthracycline cardiotoxicity

(12) Glutathione plays an important role in toxicology and homeostasis because of its ability to coordinate a variety of metal ions (13, 14), in part due to its cysteine thiol functionality

[DOI] [PubMed] [Google Scholar] 48.Rahman MT, Ghosh C, Hossain M, Linfield D, Rezaee F, Janigro D, et al

Ice crystal formation physically damages the peptide structure, creating aggregation and reducing biological activity