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Notably, the selective uptake of cystine (an oxidized dimer of cysteine), rather than methionine, as a precursor for cysteine and subsequently GSH biosynthesis imposes a further metabolic constraint: the reduction of cystine to cysteine requires NADPH, the supply of which becomes critical for GSH biosynthesis (see Supplementary Fig

Traditionally, the development of age-related cataracts has been attributed to factors such as endogenous oxidative stress, protein denaturation and aggregation, and impaired nutrient transport within the lens ( Previous studies have demonstrated that ferroptosis has important pathological implications in various age-related diseases, including neurodegenerative disorders and cardiovascular diseases ( To address this question, Wei et al

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Takeaway: May help reduce the biological wear and tear of chronic stress