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The peptide increases collagen deposition, enhances fibroblast proliferation, and improves the organization of newly formed tissue

FcRn antagonists likely block transplacental transport of IgG, as demonstrated for nipocalimab in an ex vivo placental transfusion model [341], and are unlikely to pass to the fetus, as the high affinity and limited pH-dependency of their binding to FcRn cause them to stay within FcRn-expressing cells, and not undergo extensive receptor-mediated transport

Sharp KG, Yee KM, Steward O

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