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In a mouse model, the effects are seen much sooner in epidermis than the effects seen in the connective tissue with accelerated aging phenotypes (e.g., weight loss, skin atrophy, kyphosis, osteoporosis, muscle degeneration. [7] When ROS levels are too high, it will cause senescence as previously mentioned and also a feedback loop that will cause more senescence

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[PubMed] [Google Scholar] 52.Zheng M-Q, Tang K, Zimmerman MC, Liu L, Xie B, Rozanski GJ